今天是:

杨子毅

编辑: 系统管理员    发布日期: 2015-03-06   来源:药学院

【个人简介】

姓 名

杨子毅,Yang Ziyi

性 别

 出生日期

1984.02

职 称

副教授

电 话

0510-85197769

E-mail

ziggyyang@163.com

【学术简介】

〖学习经历〗
2009.10~2013.07   英国 University of East Anglia,博士

2007.09~2009.09   沈阳药科大学药剂学专业,硕士

2003.09~2007.07   沈阳药科大学药剂学专业,学士

〖工作经历〗
2013.8~2014.9 英国 University College London 药学院,博士后

【研究领域】

[1] 难溶性药物新剂型的构建,分子分散态药物传递系统机理研究及产业化。

[2] 口服缓控释药物传递系统设计与产品开发。

[3] 纳米晶体、纳米脂质微球等微粒型药物传递系统设计及应用。

【主要论著】

[1]  Yang, Z.; Nollenberger, K.; Albers, J.; Craig, D.; Qi, S. Molecular indicators of the surface and bulk instabilities of hot melt extrudated amorphous solid dispersions. Pharmaceutical Research. 2014,  32, (4), 1210-1228.

[2]  Yang, Z.; Nollenberger, K.; Albers, J.; Moffat, J. G.;Craig, D.; Qi, S. The effect of processing on the surface physical stability of amorphous solid dispersions. European Journal of Pharmaceutics and Biopharmaceutics. 2014, 88, (3), 897-908.

[3]  Yang, Z.;Nollenberger, K.; Albers, J.;Qi, S. Molecular implications of drug-polymer solubility in understanding the de-stabilisation of solid dispersions by milling. Molecular Pharmaceutics.  2014, 11, (7), 2453-65.

[4]  Yang, Z.; Nollenberger, K.; Albers, J.; Craig, D.; Qi, S. Microstructure of an Immiscible Polymer Blend and Its Stabilization Effect on Amorphous Solid Dispersions. Molecular Pharmaceutics. 2013, 10, (7), 2767-2780

[5]  Yang, Z. Y.; Wang, L.; Tang, X.  Determination of azithromycin by ion-pair HPLC with UV detection. Journal of Pharmaceutical and Biomedical Analysis. 2009, 49, (3), 811-815.

[6]  Yang, Z. Y.; Lu, Y.; Tang, X.  Pseudoephedrine Hydrochloride Sustained-Release Pellets Prepared by a Combination of Hot-Melt Subcoating and PolymerCoating. Drug Development and Industrial Pharmacy. 2008, 34, (12), 1323-1330.

[7]  Ng, Y. C.; Yang, Z.; McAuley, W. J.; Qi, S.  Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films. European Journal of Pharmaceutics and Biopharmaceutics. 2013, 84, (3), 555-565

[8]  Qi, S.; Moffat, J. G.; Yang, Z. Early Stage Phase Separation in Pharmaceutical Solid Dispersion Thin Films under High Humidity: Improved Spatial Understanding Using Probe-Based Thermal and Spectroscopic Nanocharacterization Methods. Molecular Pharmaceutics. 2013, 10, (3), 918-930.

[9]  Lu, Y.; Zhang, Y.; Yang, Z.; Tang, X.  Formulation of an intravenous emulsion loaded with a clarithromycin–phospholipid complex and its pharmacokinetics in rats. International Journal of Pharmaceutics. 2009, 366, (1–2), 160-169.

[10] Qi, S.; McAuley, W. J;Yang, Z.;Tipduangta, P.Stabilization of low molecular weight amorphous drugs in the solid state: A material science approach. Accepted by Therapeutic Delivery-Future Science.

【科研成果及奖励】

杨子毅,现为江南大学药学院药剂学副教授,一直专注于药物新剂型开发、新型药物传递系统构建及理论研究、新药申报等工作,注重创新技术的产品转化。从攻读硕士研究生阶段开始,便参与或负责新药申报、药物制剂技术的产业化:负责开发氯雷伪麻缓释微丸的处方设计及产业化研究;参与开发SFDA3.1类新药阿奇霉素滴眼液,品种已获得临床批件。在英国攻读博士学位及从事博士后研究期间,主要从事胶态分散系药物传递系统的剂型机理、处方构建、稳定性影响因素等方面的研究,特别对难溶性药物増溶、提高口服生物利用度这一药剂学领域的难题有独到的见解。已发表SCI论文9篇(第一作者6篇),参加国际性学术会议6次。