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硕士生导师

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邬敏辰(医学院)

编辑: 系统管理员    发布日期: 2016-03-18   来源:药学院

   

【个人简介】
姓 名邬敏辰,WU Min chen性 别男出生日期1962.06职 称教授电 话0510-85328363;13057202887传 真0510-85328363E-mail biowmc@126.com

【学术简介】                

〖学习经历〗

  1979.9~1983.7  东南大学,力学,学士

  1987.9~1990.7  江南大学,粮油工程,硕士

  1997.9~2001.3  复旦大学,分子生物学,博士

〖工作经历〗

  2002.6~2008.6  江南大学,医药学院,副教授

  2008.6~2012.9  江南大学,医药学院,教授

  2012.9~至今   江南大学,无锡医学院,教授

〖学术及社会兼职〗

  中国生物化学学会会员,中国免疫学会会员,中国微生物学会会员,中国发酵工业协会会员;2011年至今担任多个国际期刊的审稿人;江苏省无锡市第十一、二、三届政协委员会委员;中国农工民主党江苏省第九、十、十一届委员会委员,无锡市第九、十、十一届委员会常务委员,江南大学支部主任委员;江南大学党风廉正建设监督员。

【主讲课程】    

  生物化学,分子生物学

【指导硕士生研究方向】    

  药学院:药学(学术型硕士研究生);制药工程(专业型硕士研究生)

  生物工程学院:生物化学与分子生物学(学术型硕士研究生);发酵工程(博士研究生、学术型硕士研究生)

【研究领域】    

  手性药物中间体的生物合成:新型糖苷水解酶类及一些用于生物合成药物中间体或精细化工产品的关键酶基因的挖掘、高效表达及酶学特性的理性改造。

【主要论著】    

主编和参编论著4部;国内外期刊发表科研论文300余篇,其中SCI收录论文50余篇。

[1] Yu T, Li JF, Zhu LJ, Hu D, Deng C, Cai YT, Wu MC. Reduction of m-chlorophenacyl chloride coupled with regeneration of NADPH by recombinant Escherichia coli cells co-expressing both carbonyl reductase and glucose 1-dehydrogenase. Annals of Microbiology, 2016, 66(1):343-350.

[2] Hu D, Tang CD, Yang B, Liu JC, Yu T, Deng C, Wu MC. Expression of a novel epoxide hydrolase of Aspergillus usamii E001 in Escherichia coli and its performance in resolution of racemic styrene oxide. J Ind Microbiol Biotechnol, 2015, 42: 671-680.

[3] Yin X, Hu D, Li JF, He Y, Zhu TD, Wu MC. Contribution of disulfide bridges to the thermostability of a type A feruloyl esterase from Aspergillus usamii. PLoS ONE, 2015, 10(5):e0126864.

[4] Hu D, Ye HH, Wu MC, Feng F, Zhu LJ, Yin X, Li JF. Chemoenzymatic preparation of (S)-p-nitrostyrene oxide from p-nitrophenacyl bromide by recombinant Escherichia coli cells expressing a novel halohydrin dehalogenase. Catalysis Communications, 2015, 69:72-75.

[5] Yin X, Li JF, Wang CJ, Hu D, Wu Q, Gu Y, Wu MC. Improvement in the thermostability of a type A feruloyl esterase, AuFaeA, from Aspergillus usamii by iterative saturation mutagenesis. Appl Microbiol Biotechnol, 2015, 99:10047-10056.

[6] Dong YH, Li JF, Hu D, Yin X, Wang CJ, Tang SH, Wu MC. Replacing a piece of loop-structure in the substrate-binding groove of Aspergillus usamii β-mannanase, AuMan5A, to improve its enzymatic properties by rational design. Appl Microbiol Biotechnol, 2015, DOI: 10.1007/s00253-015-7224-7.

[7] Wang WL, Huang C, Gao LX, Tang CL, Wang JQ, Wu MC, Sheng L, Chen HJ, Nan FJ, Li JY, Li J, Feng BN. Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors. Bioorg Med Chem Lett 2014, 24:1889-1894.

[8] Zhang HM, Li JF, Wang JQ, Yang YJ, Wu MC. Determinants for the improved thermostability of a mesophilic family 11 xylanase predicted by computational methods. Biotechnol Biofuels, 2014, 7(1):3.

[9] Yin X, Yao Y, Wu MC, Zhu TD, Zeng Y, Pang QF. A unique disulfide bridge of the thermophilic xylanase SyXyn11 plays a key role in its thermostability. Biochemistry (MOSCOW), 2014, 79(6): 531-537.

[10] Li JF, Wei XH, Tang CD, Wang JQ, Zhao M, Pang QF, Wu MC. Directed modification of the Aspergillus usamii β-mannanase to improve its substrate affinity by in silico design and site-directed mutagenesis. J Ind Microbiol Biotechnol, 2014, 41(4):693-700.

[11] Zhang HM, Wang JQ, Wu MC, Gao SJ, Li JF, Yang YJ. Optimized expression, purification and characterization of a family 11 xylanase (AuXyn11A) from Aspergillus usamii E001 in Pichia pastoris. J Sci Food Agric, 2014, 94(4):699-706.

[12] Li JF, Zhang HM, Wu MC, Wang CJ, Dong YH, Zhu LJ, Zhang P. Expression and characterization of hyperthermotolerant xylanases, SyXyn11P and SyXyn11E, in Pichia pastoris and Escherichia coli. Appl Biochem Biotechnol, 2014, 172(7):3476-3487.

[13] Tan ZB, Li JF, Wu MC, Wang JQ. Enhancing the thermostability of a Cold-Active Lipase from Penicillium cyclopium by In Silico Design of a Disulfide Bridge. Appl Biochem Biotechnol, 2014, 173:1752-1764.

[14] Wang JQ, Tan ZB, Wu MC, Li JF, Wu J. Improving the thermostability of a mesophilic family 10 xylanase, AuXyn10A, from Aspergillus usamii by in silico design. J Ind Microbiol Biotechnol, 2014, 41:1217-1225.

[15] Tan ZB, Li JF, Li XT, Gu Y, Wu MC, Wu J, Wang JQ. A Unique Mono- and Diacylglycerol Lipase from Penicillium cyclopium: Heterologous Expression, Biochemical Characterization and Molecular Basis for Its Substrate Selectivity. Plos One, 2014, 9(7):e102040.

[16] Tang CD, Guo J, Li JF, Wei XH, Hu D, Gao SJ, Yin X, Wu MC. Enhancing expression level of an acidophilic β-mannanase in Pichia pastoris by double vector system. Ann Microbiol, 2014, 64:561-569.

[17] Zeng Y, Yin X, Wu MC, Yu T, Feng F, Zhu TD, Pang QF. Expression of a novel feruloyl esterase from Aspergillus oryzae in Pichia pastoris with esterification activity. J Mol Catal B-Enzym, 2014, 110:140-146.

[18] Tan ZB, Tang CD, Wu MC, He Y, Hu D, Wang JQ. Exploration of Disulfide Bridge and N-Glycosylation Contributing to High Thermostability of a Hybrid Xylanase. Protein & Peptide Letters, 2014, 21(8).

[19] Luo QL, Wu J, Wu MC. Enhanced acetoin production by Bacillus amyloliquefaciens through improved acetoin tolerance. Process Biochem, 2014, 49:1223-1230.

[20] Gao SJ, Wang JQ, Wu MC, Zhang HM, Yin X, Li JF. Engineering hyperthermostability into a mesophilic family 11 xylanase from Aspergillus oryzae by in silico design of N-terminus substitution. Biotechnol Bioeng, 2013, 110(4), 1028-1038.

【科研项目】    

  主持或主要参与国家自然科学基金3项,国家、省、校级和企业委托科研项目30余项,指导国家大学生创新性实验计划项目3项,江苏省创新计划项目7项,江南大学博士研究生科学研究基金项目3项。

【科研成果及奖励】    

  [1] 部、省、市科技成果鉴定7项;

  [2] 全国、协会、市级科技和教学成果奖10余项;

  [3] 无锡市具有突出贡献的中青年专家;

  [4] 江南大学青蓝工程优秀青年骨干教师;

  [5] 江南大学03~05年度优秀教育工作者。

【主要授权专利】    

  获授权或申请技术发明专利30余项。

  [1] 利用PCR确定已知DNA序列的两侧未知序列的方法,中国发明专利:ZL02137474.0

  [2] 一种利用宇佐美曲霉产业化生产木聚糖酶的方法,中国发明专利:ZL200710022405.5

  [3] 一种利用黑曲霉生产β-甘露聚糖酶的方法,中国发明专利:ZL200710022406.X

【在读硕、博士人数】    

  博士生2人,硕士生8人

【已毕业硕、博士人数】    

  博士生5人,硕士生40人

【指导本科生人数】    

  近三年指导本科生10人

【以上资料更新日期】    

  2016年3月