教授简介

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龚笑海

     

姓名

GONGXIAOHAI

性别

出生年月

1961.09

党派

职称

客座教授

民族

最高学位

博士

毕业

UT MD Anderson Cancer Center

联系方式

15061868131

254450806@qq.com

研究方向

药学/药剂学

主要学习工作简历和主要学术兼职

【学习和工作经历】

2015.1-至今  Wuxi   Paribio Inc. Wuxi, China

Founder, Executive   board director, CSO

2010.2-2015.1 Wuxi BioHermes Inc. MaShan, Wuxi, China

Founder, Executive   board director, CSO

1999.11-2010.1 Wyeth Pharmaceuticals, (Acquired   by Pfizer 2009) Princeton, NJ

Sr. Research   Scientist II (group leader)

1997.4-1999.10  Lexicon Pharmaceuticals,   Woodlands, TX

Sr. Research   Scientist I (PhD level, project leader)

1990.9-1997.3 UT MD Anderson Cancer Center, Houston,   TX

Sr. Research   Scientist (lab manager)

1983.8-1990.9 Shanghai institute of Biochemistry,   Chinese Academy of Science

Sr. Research   scientist

科学研究情况简介

【学科建设方面】

龚笑海教授于2014年首次发起并组织了国际生物医药产学研论坛在无锡江南大学药学院的召开,该论坛每年邀请国际前言生物医药研究者对国际医药产业的前言进行深度剖析,对生物制药人才的培养模式具有十分重要的意义。龚笑海教授负责每年参会人员的邀请及会议的主持,随着影响力度的加大,现由江南大学、无锡市食品药品监督管理局以及无锡市对外科技交流中心共同主办,截止目前国际生物医药产学研论坛已经召开四届(2014-2017),对我校的生物医药学科建设起到了积极导向作用。

【近年来主要及协助研究课题】

[1] PARP抑制剂类小分子与中国人胰腺癌的治疗

[2] BMP10活性蛋白的表达鉴定及其在心脏保护方面的应用

[3] 药物高通量筛选平台的构建-与美国Origene公司的合作

[4] 长效糖尿病治疗创新药物GLP-1的研制及产业化研究

[5] DNA修复酶PNKP与肿瘤耐药的相关性研究

【近年来辅导发表论文】

1. Chen Shuxian, Wang Xu, Ye Xianghui, Gong xiaohai, et al. Identification   of human UMP/CMP kinase 1 as doxorubicin binding target using protein   microarray. J Biomol Screen, 2017,   22: 1007-1015.

2. Fu   Qianyun, Chen Zhen, Gong Xiaohai,   et al. β-Catenin expression is regulated by an IRES-dependent mechanism and   stimulated by paclitaxel in human ovarian cancer cells. Biochem and Bioph Res Co, 2015, 416: 21-27.

3. Qian   Kai, Gong Xiaohai, Guan Bo, et al.   Efficient expression of glucagon-like peptide-1 analogue with human serum   albumin fusion protein in Pichia pastoris using the   glyceraldehyde-3-phosphate dehydrogenase promoter. Biotechnol Bioproc E, 2015, 20: 694-700.

4. Qian   Kai, Li Chengyuan, Gong Xiaohai,   et al. Expression of a glucagon-like   peptide-1 analogue, as a therapeutic agent for type II diabetes, with   enhanced bioactivity and increased N-terminal homogeneity in Pichia pastoris.   Biotechnol Lett, 2015, 37: 2229–2235.

5. Yang Xueli, Ndawula Jr Charles, Zhou   Haiyan, Gong Xiaohai, Jin Jian. JF-305, a pancreatic   cancer cell line is highly sensitive to the PARP inhibitor olaparib. Oncol   lett, 2015, 9: 757-761.

6. Charles   Ndawula Jr., Xueli Yang, Xiaohai Gong, Jian Jin CHK21100delC, I157T, IVS2 +IG > A, BRCA1   and BRCA2 Mutation Analysis in JF305: A Pancreatic Cancer Cell Line Journal   of Biosciences and Medicines, 2014, 2, 58-67

7. Xueli   Yang, Charles Ndawula, Haiyan Zhou, Xiaohai Gong, Jian Jin JF-305, a pancreatic cancer cell line is   highly sensitive to the PARP inhibitor olaparib. Oncol Lett 2015 Feb 3;9(2):757-761.  

8. Muhammad   Imran Amirzada, Xin Ma, Xiaohai Gong, Yun Chen, Sajid Bashir, Jian   Jin Recombinant human interleukin 24   reverses Adriamycin resistance in a human breast cancer cell line. Pharmacol   Rep 2014 Oct 6;66(5):915-9.

9. Muhammad   Imran Amirzada, Minglei Yu, Xiaohai Gong, Yun Chen, Ruiyu Zhu,   Jianyong Lei, Jian Jin Cost-effective   production of recombinant human interleukin 24 by lactose induction and a   two-step denaturing and one-step refolding method. J Ind Microbiol Biotechnol 2014 Jan   31;41(1):135-42.

10. Haiyan   Zhou, Jun Ma, Xueli Yang, Xiaohai Gong, Qiuping Li, Jian Jin Expression and purification of hPARP1 by   baculovirus system. Sheng Wu Gong Cheng Xue Bao 2013   Jul;29(7):998-1005

11. Bo Guan,   Jianyong Lei, Shuai Su, Fengxiang Chen, Zuoying Duan, Yun Chen, Xiaohai   Gong, Huazhong Li, Jian Jin Absence of Yps7p, a putative   glycosylphosphatidylinositol-linked aspartyl protease in Pichia pastoris, results   in aberrant cell wall composition and increased osmotic stress resistance. FEMS   Yeast Res 2012 Dec 25;12(8):969-79.

12. Robert L. Martone, Hua Zhou, Kevin Atchison, Thomas   Comery, Jane Z. Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft,   Boyd Harrison, Scott Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret   Zaleska, Davidc R. Riddell, Erik Wagner, Peimin Lu, Roy Sun, June   Sonnenberg-Reines, Aram Oganesian, Karissa Adkins, Donna Huryn, Magid   Abou-Gharbia, Ronald Magolda, Jonathan Bard, Jeffrey Paul, Glen Frick,   Sangeeta Raje, S. Bradley Forlow, Carrie Balliet, Michael E. Burzynski, Peter   Reinhart, Hong L. Wan, Menelas N. Pangalos, J. Steven Jacobsen* GSI-953   (Begacestat): A novel, selective thiophene sulfonamide inhibitor of APP   γ-secretase for the treatment of Alzheimer’s disease Journal of Pharmacology and Experimental   Therapeutics 2009, 331:598–608

13. Jie   Zhang , Diana Chen , Xiaohai Gong , Huaiping Ling , Guoming Zhang ,   Andrew Wood , Julia Heinrich , Seongeun Cho Cyclic-AMP Response Element-Based Signaling Assays for   Characterization of Trk Family Tyrosine Kinases Modulators. Neurosignals, 2006 Jul 6;15 (1): 26-39  

14. Feng   Liu, Xiaohai Gong, Guoming Zhang, Karen Marquis, Peter Reinhart and Terrance   H. Andree The inhibition of glycogen synthase kinase 3b by a metabotropic   glutamate receptor 5 mediated pathway confers neuroprotection to Aâ peptides. Journal   of Neurochemistry, 2005, 95, 1363–1372

工程背景

1. 创办了无锡博慧斯(BioHermes)生物医药科技有限公司 创办人兼技术总工

尤以体外检测见长,研发并申报有国际专利的博唐平 A1C EZ(糖化血红蛋白检测仪),2014年估值3亿人民币;

2. 创办了江苏爱尔康(EyeCure)生物医药科技有限公司 创办人兼技术总工

国际眼科细胞和基因治疗领跑者,实现了人源RPE细胞的临床治疗老年性视网膜黄斑变性等疾病,2018年估值2亿人民币。

【以上资料更新日期】20186