教授简介

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张燕

 

【个人简介】

姓名 张燕 Yan Zhang

性别 女

出生日期 1986.05

职称 校聘研究员

E-mail zhangyanyz@jiangnan.edu.cn

【学术简介】

〖学习经历〗

2009.92013.8 瑞典皇家理工学院,有机化学,博士

2008.92009.6 中国药科大学,药物化学,研究生学习

2004.92008.6 中南大学,药学,学士

〖工作经历〗

2017.11至今江南大学药学院,校聘研究员

2015.112017.10法国国家科学研究中心-欧洲膜技术研究所,博士后

2014.112015.10法国国家科学研究中心-欧洲膜技术研究所,玛丽居里DYNANO项目研究员

2014.72014.9新加坡国立大学,有机化学,博士后

2013.92013.11瑞典皇家理工学院,有机化学,博士后

2013.82013.10瑞典皇家理工学院,“选择性有机合成”课程,实验课教师

〖学术及社会兼职〗

【研究领域】

[1]动态键水凝胶材料在三维细胞培养中的应用。

[2]动态化学在生物分子识别中的应用。

[3]动态组合化学在先导化合物的发现和药物传递中的应用。

【主要论著】

期刊文章:

Y. Zhang, C. T. Supuran, M. Barboiu*, Exponential Activation of Carbonic Anhydrase by Encapsulation in Dynameric Host Matrices with Chiral Discrimination.Chem. Eur. J., DOI: 10.1002/chem.201704605

Y. Li,Y. Zhang, Y.-M. Legrand, A. van der Lee, J. Jiang, C. Chen, C. Su and M. Barboiu*. Hydrophobic metallo-supramolecular Pd2L4 Cages for zwitterionic guest encapsulation in organic solvents.Dalton Trans.,2017,46, 15204.

W. Feng, Z. Sun,Y. Zhang, Y. Legrand, E. Petit, C. Su, M. Barboiu*. Bis-15-crown-5-ether-pillar[5]arene K+-responsive channels.Org. Lett. 2017,19, 1438.

Y. Zhang, W. Feng, Y. Legrand, C. Supuran, C. Su and M. Barboiu*. Dynameric host frameworks for the activation of lipase through H-bond and interfacial encapsulation.Chem. Commun.,2016.52, 13768.

Y. Zhang, S. Jayawardena, M. Yan, O. Ramström*. Enzyme classification using complex dynamic hemithioacetalsystems.Chem. Commun.,2016,52, 5053.

Y. Zhang, Y. Legrand, P. Eddy, C.Supuran, M, Barboiu*. Dynamic encapsulation and activation of carbonic anhydrase in multivalent dynameric host matrixes.Chem. Commun.,2016,52, 4053.

Y. Zhang, Y. Legrand, A. Lee, M. Barboiu*. Ligand- and metal-driven selection of flexible adaptive dynamic host receptors.Eur. J. Org. Chem.2016, 2016, 1825.

Y. Zhang, M. Barboiu*. Constitutional dynamic materials - towards natural selection of function.Chem. Rev.2016,116, 809.

Y. Zhang, M. Barboiu*. Dynameric asymmetric membranes for directional water transport. Chem. Commun.2015.51, 15925.

Y. Zhang, Y. Zhang, Y. Ren, O. Ramström*. Synthesis of chiral oxazolidinone derivatives through lipase-catalyzed kinetic resolution.J. Mol. Catal. B: Enzym.2015,122, 29.

L. Hu,Y. Zhang, O. Ramström*. Lipase-catalyzed dynamic kinetic asymmetric transformation to oxathiazinanones.Org. Biomol. Chem.2014,12, 3572.

Y. Zhang, F. Schaufelberger, M. Sakulsombat, C. Liu and O. Ramström*. Asymmetric synthesis of 1,3-oxathiolan-5-one derivatives through dynamic covalent kinetic resolution.Tetrahedron2014,70, 3826.

Y. Zhang, P. Vongvilai, M. Sakulsombat, A. Fischer and O. Ramström*. Asymmetric synthesis of substituted thiolanes through domino thia-Michael-Henry dynamic covalent systemic resolution using lipase catalysis.Adv. Synth. Catal.2014,356, 987.

Y. Zhang, and O. Ramström*. Thiazolidinones from dynamic systemic resolution of complex reversible reaction networks.Chem. Eur. J.,2014,20, 3288.

L. Hu, F. Schaufelberger,Y. Zhangand O. Ramström*. Efficient asymmetric synthesis of Lamivudine via enzymatic dynamic kinetic resolution.Chem. Commun.2013, 49, 10376.

Y. Zhang, L. Hu and O. Ramstrom*. Double parallel dynamic resolution through lipase-catalyzed asymmetric transformation.Chem. Commun.,2013, 49, 1805.

M. Sakulsombat,Y. Zhangand O. Ramström*. Dynamic asymmetric hemithioacetal transformation by lipase-catalyzed γ-lactonization: in situ tandem formation of 1,3-oxathiolan-5-one derivatives.Chem. Eur. J.,2012,18, 6129.

Y. Zhang, M. Angelin, R. Larsson, A. Albers, A. Simons and O. Ramström*. Tandem driven dynamic self-inhibition of acetylcholinesterase.Chem. Commun., 2010,46, 8457.

书籍章节:

Y. Zhangand M. Barboiu*. Self-assembly in dynamic systems. J. Atwood, eds.,Comprehensive Supramolecular Chemistry II. Elsevier,2017.

Y. Zhang, L. Hu, O. Ramström*. Constitutional dynamic chemistry for bioactive compounds. H.-J. Schneider, eds.,Supramolecular Systems in Biomedical Fields.RSC, UK,2013.

M. Sakulsombat,Y. Zhangand O. Ramström*. Dynamic systemic resolution.Top. Curr. Chem.,2012, 322, 55.

 

【在研科研项目】

 

【科研成果及奖励】

 

【以上资料更新日期】

20181